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filingDate 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4103583-A1
titleOfInvention Tandem repeat cancer-targeting peptides for molecular conjugation or engineering and uses thereof in cancer theranostics
abstract An isolated cancer-targeting peptide that includes at least two copies of the amino acid sequence PFLP (SEQ ID NO: 1) or PELF (SEQ ID NO: 2). Also disclosed is a pharmaceutical composition for treating cancer. The composition contains the isolated cancer-targeting peptide and an anti-cancer agent. Further disclosed is a bispecific anti-cancer antibody that includes the isolated cancer targeting peptide and an antigen-binding peptide that stimulates T cell activity. Methods are provided for treating cancer by administering the pharmaceutical composition or the bispecific anti-cancer antibody. Further provided is a method for diagnosing cancer by administering a radionuclide-labeled cancer-targeting peptide to an individual and imaging a location of the radionuclide.
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