| abstract |
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ ID NOS: 4-370, 391-440, and 448-833 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 4-370, 391-440, and 448-833, as well as methods of producing and using the same. The present is further directed to detolerized antigens to the regulatory T cell epitopes, including proteins or polypeptides of SARS-CoV-2 wherein one or more of the dentified T cell epitopes are deleted, partially deleted and/or mutated. |