http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4103160-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2a3a767ae32dfcda1f4e6642aeadc9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2021-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50423d059977583ab89331ca93fd1fea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab3a1d5560975b678dcfc58e828b0351 |
| publicationDate | 2022-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-4103160-A1 |
| titleOfInvention | Nanoparticles encapsulating small molecules |
| abstract | The invention relates to a lipoprotein cage for intracellular delivery of cargo, said lipoprotein cage comprises (i) a protein cage comprising at least one polypeptide comprising an amino acid sequence I consisting of SEQ ID NO: 1, wherein said protein cage possesses a positively charged interior; and (ii) a surfactant composition comprising one or more amphiphiles, wherein the one or more amphiphiles are selected such that the net charge of the composition is negative, wherein said surfactant composition is encapsulated into the assembled protein cage. The invention further relates to complex comprising the lipoprotein cage of the invention and one or more cargo molecules, and to a method for manufacturing the lipoprotein cage of the invention comprising the steps of self-assembling of a protein cage from at least one polypeptide comprising an amino acid sequence I, preferably from 24 polypeptides each comprising the amino acid sequence I, and encapsulating the anionic amphiphile of the invention into the protein cage, without disassembly of the protein cage. |
| priorityDate | 2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 308.