http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4100877-A1

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filingDate 2021-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7da22fbb0aa7d7eaa515390e53caa104
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publicationDate 2022-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4100877-A1
titleOfInvention Computer-implemented method, computer program and surgical system for determining the volumetric flow rate of blood through a portion of a blood vessel in a surgical field
abstract The invention relates to a computer-implement method (10) for determining the volumetric flow rate of blood (IBI) through a portion (90i, i = 1, 2, 3, ...) of a blood vessel (88) in a surgical field (36) using a fluorophore. A plurality of images (801, 802, 803, 804, ...) is provided, which are based on fluorescent light in the form of light having wavelengths lying within a fluorescence spectrum of the fluorophore and which show the portion (90i) of the blood vessel (88) at different recording times (t1, t2, t3, t4, ...). By means of the processing of at least one of the provided images (801, 802, 803, 804, ...), a diameter (D) and a length (L) of the portion (90i) of the blood vessel (88) and a time interval for the propagation of the fluorophore through the portion (90i) of the blood vessel (88) are ascertained, which time interval indicates a characteristic transit time (T) for the fluorophore in the portion (90i) of the blood vessel (88). A blood vessel model (I) is specified for the portion (90i) of the blood vessel (88), which blood vessel model describes the portion (90i) of the blood vessel (88) as a flow channel (94) having a length (L), having a wall (95) with a wall thickness (d) and having a free cross-section Q. A fluid flow model (II) for the blood vessel model (I) is assumed, which fluid flow model describes a local flow velocity (122) at different positions over the free cross-section Q of the flow channel (94) in the blood vessel model (I), and a fluorescent light model (III) is assumed, which describes a spatial probability density for the intensity of the remitted light at difference positions over the cross-section Q of the flow channel (94) in the blood vessel model (I), which light is emitted by a fluid, which is mixed with fluorophore and flows through the free cross-section Q of the flow channel (94) in the blood vessel model (I), when said fluid is irradiated with fluorescence excitation light. The volumetric flow rate of blood (IBI) is determined as a fluid flow guided through the flow channel (94) in the blood vessel model (I), which fluid flow is calculated from the length (L) and the diameter (D) of the portion (90i) of the blood vessel (88) and from the characteristic transit time (T) for the fluorophore in the portion (90i) of the blood vessel (88) using the fluid flow model (II) and the fluorescent light model (III).
priorityDate 2020-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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