| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8179d07d2366fdab43b0895c2984d09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-12 |
| filingDate |
2021-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_633e1b11e3b0cd72bceee5d703fe026d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06523ced3062f738ee2265c881106de4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d801de86439c6bb3a148506f15c9e405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ec12e4006823349d6d34225e1733ef3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b482145d31990b448a329f5e5b5580a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e531f0bbeab18a636ed102863589e56 |
| publicationDate |
2022-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-4097109-A1 |
| titleOfInvention |
Process for the synthesis of buprenorphine |
| abstract |
The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of the baine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine. |
| priorityDate |
2020-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |