| abstract |
Provided is a method of producing an antibody-drug conjugate represented by Formula (I),n nin the formula, Ab is an antibody or an antigen-binding fragment thereof, D is eribulin, m is an integer of 1 to 10, and p is an integer of 1 to 8, nthe method comprising: na step 1 of obtaining a compound represented by Formula (B) by reaction of eribulin or a salt thereof with a compound represented by Formula (A),n in the formula, m is an integer of 1 to 10 and X is a phenoxy group or a nitrophenoxy group, andn in the formula, m is an integer of 1 to 10, and na step 2 of obtaining the antibody-drug conjugate represented by Formula (I) by reaction of the compound represented by Formula (B) with Ab. |