| abstract |
Provided is a polypeptide, comprising, from N-terminus to C-terminus, a) at least a variable region of a heavy chain of a heavy-chain antibody (VHH domain) that binds protein Programmed Death Ligand 1 (PD-L1), operably linked to IgG Fc binding domain; and b) human TGFβRII, or a fragment thereof capable of binding TGFβ. An antibody comprises the said polypeptide, the amino acid sequences of the said antibody, cloning or expression vectors, cells and methods for expressing or isolating the antibodies are further provided. Therapeutic compositions comprising the said antibodies, and the methods for treating cancers and other diseases with the bispecific antibodies are also provided. |