http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4067366-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb2651d5e254745841d10fd3e5467a90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2021-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d136500fa86ba7ec64cb8b5da323b34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4679b22cbfa44183e893a4225ef9b6c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c6140a357443877081bdde8cc16f0e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2086068128526b5bbe7f74ff3bfa9410 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f5a1c3229161dd675539b2ff3620e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d8cf45000adc7abad2709e2fee4fda4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98547ca02db8aa097aabf8da2fce2cb7 |
| publicationDate | 2022-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-4067366-A1 |
| titleOfInvention | Method for purifying progesterone |
| abstract | The present disclosure provides a purification method of progesterone, and belongs to the technical field of preparation process of steroids. In this method, aldehyde impurities in a progesterone crude product react with a sulfurated nucleophile to yield highly polar hydroxysulfonates and progesterone to realize solubility differentiation, and highly pure progesterone with a content higher than 99.5% and a total aldehyde impurities content lower than 0.2% is obtained through elutriation, filtration, washing a filter cake with water, and drying. The purification method provided by the present disclosure avoids the technical bottleneck of progesterone purification in the prior art, and all reagents and raw materials used during the reaction are inexpensive and easily available, with low equipment requirement and cost input; the purification process is mild and safe, conditions are easy to control, and the purification and recovery rate of the product is high; reagents used cause little environmental pollution, and particularly highly polluting chromium-containing reagents are not used. Thus, the method coincides with the development trend of the green chemical industry and has excellent economic and social benefits. |
| priorityDate | 2020-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID5994 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226399016 |
Total number of triples: 21.