| abstract |
Disclosed is a nano complex for the targeted repairing of a neurovascular lesion. The nano complex comprises a lipid, an apolipoprotein and a targeted peptide, and the targeted peptide is formed by covalently linking, by means of a bridge structure, a nanocarrier linking end and a peptide chain which targets RAGE, which specifically binds to cerebrovascular lesion site. On the basis of AD and the high expression of RAGE in cerebrovascular and brain parenchyma in diabetic encephalopathy, the nano complex, which has been modified by the targeted peptide, is capable of mainly binding, in a targeted manner, to the cerebrovascular endothelium by means of linking the targeted peptide, so as to repair vascular endothelial cells, promote the removal of Aβ plaque near blood vessels, and repair cerebrovascular and neurovascular unit components such as microglial cells, astrocytes and neurons. The aim of ameliorating cognitive impairment is achieved by the combined repairing of multiple components and then restoring cerebrovascular functions and cerebral blood flow. The nano complex itself has a disease repair effect and can also carry drugs, thereby achieving the delivery of drugs to cerebrovascular lesion site. |