http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4043562-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d0e1705700a059b200c774b76ce1234 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-01 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-06008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate | 2021-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3eda824ce50aa60b7c2941b47ffaa36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbf953da628e0d5c6d8740ecc02efcf2 |
| publicationDate | 2022-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-4043562-A1 |
| titleOfInvention | Mutated arylsulfatase a with increased stability |
| abstract | The invention is based on the introduction of mutations into the amino acid sequence of human Arylsulfatase A (ASA or ARSA) in order to increase protein stability. The invention introduces amino acid mutations, such as deletions, substitutions or additions, into the C-terminal part of the human ARSA enzyme, in particular at a position around or at amino acid 424, which result in a sequence that does not comprise E424. Provided are further nucleic acids and vectors for the expression of the mutated ARSA of the invention, recombinant cells and pharmaceutical composition comprising the mutated ARSA, as well as its use in the treatment of diseases that are characterized by a reduced activity of endogenous ARSA. |
| priorityDate | 2021-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 242.