| abstract |
A lyophilized composition capable of encapsulating any nucleic acid with high efficiency and easily is provided. A lyophilized composition of lipid nanoparticles not containing a nucleic acid but containing an ionic lipid, a sterol, a PEG lipid, an acidic buffer component that shows a buffering action at pH 1 - 6, and a cryoprotectant, wherein a weight ratio of the cryoprotectant and a total lipid is 10:1 - 1000:1. |