| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bf346bdac1574b717e1bd370a8a7fe3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B50-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N3-123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-20 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-00 |
| filingDate |
2022-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_867821f1807aa4c5b9140654d64dc990
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad0da3db513ea3eba03a5de9b482d92c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_694b7740eea388000cb0f95604a8da92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dddc445adc10695eccb16d13c4396898
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c954dd85dd63080f5a71c2c7d2eac243
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa36b80eb7c2b08e176c748a47c88f7d |
| publicationDate |
2022-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-4030438-A1 |
| titleOfInvention |
Systems and methods for sequence design |
| abstract |
A messenger RNA (mRNA) vaccine has emerged as a promising direction to combat the COVID-19 pandemic. This requires an mRNA sequence that is stable and highly productive in protein expression, features to benefit from greater mRNA secondary structure folding stability and optimal codon usage. Sequence design remains challenging due to the exponentially many synonymous mRNA sequences encoding the same protein. The present disclosure presents embodiments of a linear-time approximation (LinearDesign) reducing the design to an intersection between a Stochastic Context Free Grammar (SCFG) and a Deterministic Finite Automaton (DFA). Embodiments of the LinearDesign may implement an mRNA sequence design using much reduced time with very limited loss. Various methodologies, e.g., finding alternative sequences based on k-best parsing or directly incorporating codon optimality, are presented for incorporating the codon optimality into the design. Embodiments of the LinearDesign may provide efficient computational tools to speed up and improve mRNA vaccine development. |
| priorityDate |
2021-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |