| abstract |
A chidamide pharmaceutical composition, a preparation method therefor and an application thereof. The pharmaceutical composition comprises chidamide and a pharmaceutically acceptable enteric excipient that severe as a carrier. In the pharmaceutical composition, chidamide is used as a guest molecule, and the pharmaceutically acceptable enteric excipient is used as a carrier molecule. Oral pharmacokinetic testing on animal proves that the bioavailability of the composition comprising chidamide and the pharmaceutically acceptable enteric excipient is greatly improved, while adverse reactions caused by the drug in the gastrointestinal tract are reduced; in addition, the dosage may be reduced while maintaining the curative effect, thus having more important clinical significance than commercially available chidamide tablets. |