| abstract |
Disclosed are a hydrogel patch, which controls syneresis of a hydrogel so as to enhance transdermal delivery of an active ingredient and has good physical properties, and a preparation method therefor. The hydrogel patch contains: a hydrogel composed of a mixture of phase A consisting of a crosslinking agent and purified water, phase B consisting of an organic polymer and a polyhydric alcohol, and phase C consisting of a pH adjusting agent and purified water; and a filling solution composed of a mixture of phase D consisting of a humectant and purified water, phase E consisting of a thickener and a polyhydric alcohol, and phase F consisting of a pH adjusting agent and purified water. The hydrogel of composition A is filled with the filling solution of composition C, and the hydrogel of composition B is filled with the filling solution of composition D. |