http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4016044-A1

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-30
filingDate 2020-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_304c104874affeb6ada8d5971e889847
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84907fba81623db576fc59a6eabc6f7d
publicationDate 2022-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4016044-A1
titleOfInvention Improved method for optically clarifying a tissue sample for microscopic examination
abstract The invention relates to a method for producing transparent tissue samples of a biological or human tissue for light microscopic examination, comprising the steps of a) dehydrating the tissue sample with a dehydrating solvent and b) clarifying the dehydrated tissue sample by placing it in an embedding medium containing an aromatic ester. The aromatic ester is a phenylacetic acid ester. Compared to the previously commonly used embedding media benzyl benzoate/benzyl alcohol mixtures and methyl salicylate-benzyl benzoate mixtures, the aromatic esters have the advantage that, just like dibenzyl ether, they can be used as a pure substance: since the pure substance already achieves the desired refractive index, the Refractive index cannot be adjusted by mixing the embedding medium. In addition, they are non-toxic, have low volatility and allow the transparent fabric to be stored refrigerated.
priorityDate 2020-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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