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filingDate 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4015637-A1
titleOfInvention Producer cell line having low levels of va rna
abstract The present invention relates to host cells comprising a nucleic acid encoding an Adeno-associated virus (AAV) capsid protein, wherein the protein kinase R (PKR) activating sequence surrounding the start codon of AAV capsid protein VP1 is inactivated, while maintaining functional expression of the AAV capsid proteins VP1, VP2, and VP3. The present invention further relates to methods for the production of Adeno-associated virus (AAV), comprising the step of expressing said AAV in the host cells of the present invention.
priorityDate 2020-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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