| abstract |
The present invention pertains to an improved composition of cells enriched in regulatory T (Treg) cells and a method for producing the same. In particular, the invention provides a novel strategy to produce such compositions of cells enriched in Tregs, comprising identifying, isolating and expanding cells positive for T cell immune response cDNA 7 (TIRC7) protein as well as CD25. The compositions enriched in Tregs prepared in accordance with the methodology of the invention are particularly useful for medical applications such as the treatment of immunological disorders and infectious diseases. Thus, the present disclosure offers a promising novel treatment approach as a cell-based therapy for patients suffering from immunological disorders, such as allergy, asthma, autoimmune disorders, graft versus host disease (GVHD), and transplantation graft rejection, or infectious diseases. |