| abstract |
The present disclosure provides pharmaceutical compositions comprising a first opioid antagonist and a second opioid antagonist, wherein the first opioid antagonist has a half-life in plasma that is of shorter duration than the half-life of the second opioid antagonist in the plasma and wherein the second opioid antagonist is encapsulated within liposomes. The composition may be embedded or entrapped within a water insoluble, water absorbable polymeric matrix, to form a composite water. The pharmaceutical composition or the composite material can be used in a method of counteracting opioid overdose in a subject by administering the same, preferably by intramuscular injection, to the subject. |