| abstract |
The present invention relates to a transformed cell of bacteria of the genus Bacillus, more particularly B. subtilis, which produces hyaluronic acid, the cell comprising in its chromosome a fusion of heterologous hasA gene from S. equisimilis with tuaD gene of B. subtilis under control of the hybrid tandem promoter P<sub>rpsF-gsiB</sub>, and optionally gtaB gene under control of the hybrid tandem promoter P<sub>rpsF-gsiB</sub> and/or gcaD-prs operon under control of the hybrid tandem promoter P<sub>rpsF-gsiB</sub>. The present invention also relates to a method for producing hyaluronic acid by said transformed cell. |