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filingDate 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-4005382-A1
titleOfInvention Perfusion fluid and perfusion method
abstract A perfusion method includes a) cleaning a blood vessel of an organ by causing a first perfusate to flow into the blood vessel and letting the first perfusate out of the organ through the blood vessel, and b) after the operation a), preserving the organ while causing a second perfusate to flow into the blood vessel and letting the second perfusate out of the organ through the blood vessel. The first perfusate and the second perfusate each contain a biocompatible solution and a serine protease and have an osmotic pressure ratio higher than or equal to 1 and lower than or equal to 5 relative to the saline solution. The concentration of the serine protease in the second perfusate is lower than that in the first perfusate and is higher than or equal to 0.01 mg/mL and lower than or equal to 100 mg/mL. Accordingly, it is possible to dissolve thrombi in the blood vessel of the organ or prevent the formation of new thrombi during organ perfusion treatment.
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