http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4004925-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_134e761e8dcbff4985fa1e77a9c2062e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-20 |
| filingDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15c7f08555e9208ba982d5c9174cb578 |
| publicationDate | 2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-4004925-A1 |
| titleOfInvention | Method for generating variants of a protein |
| abstract | The present relates to a method for generating variants of a protein based on a native protein regulated by allosteric pathway, the method comprising: - i) providing 3D structures of the native protein; - ii) identifying at least one pair of coupled allosteric sites within the amino acid sequence of the native protein named microswitch; - iii) generating in silico mutations of said identified microswitch to generate a pool of variants; - iv) computing at least one score reflecting the variation in allosteric coupling; and/or the variation in the relative stability - v) predicting the activity of each variant compared to the native protein based on the computed score. The invention also concern a computer implemented program to carry out said method, and a variant of a protein or an active fragment thereof, a polynucleotide. |
| priorityDate | 2019-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 315.