| abstract |
Disclosed are topical compositions and methods of treatment of a skin or mucosal disorder selected from palmoplantar psoriasis, hereditary palmoplantar keratoderma, acquired palmoplantar keratoderma, hydradenitis suppurativa, dermatitis, ichthyosis vulgaris, hereditary ichthyosis, acquired ichthyosis, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, Gorlin syndrome, nail psoriasis, flexural/inverse psoriasis, non-melanoma skin cancer and precancerous skin, mucosal and nail lesions, by once or twice daily topical administration to a subject of a composition comprising as active agent(s) therapeutically effective amounts of tapinarof, at least one EGFR inhibitor or tapinarof-EGFR inhibitor(s) combinations. |