http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4001268-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53985c72f910b913d8bafcf49ed074a6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-24 |
| filingDate | 2020-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c50685840fee2af30b8ecc95d24cbe5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b842de6441afc0162fdc4dd91357c0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ba4b6c93d424e031a7fde81ca9425d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4ad94e32d9c7a27329c1a81aa74c09c |
| publicationDate | 2022-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-4001268-A1 |
| titleOfInvention | Method for synthesizing n-substituted phenyl-5-hydroxymethyl-2-oxazolidinone |
| abstract | The invention discloses a method for synthesizing N-substituted phenyl-5-hydroxymethyl-2-oxazolidinone, wherein the method comprises: reacting from raw materials, 3-R2-4-R1-aniline and epichlorohydrin, and allowing the resulting product to react under alkaline conditions in a CO 2 atmosphere to obtain N-substituted phenyl-5-hydroxymethyl-2-oxazolidinone, wherein R 1 is a morpholine group, a morpholin-3-one group or a piperazine group, and derivative groups thereof, and R 2 is halogen, hydrogen or lower alkyl. The method provided by the invention has such advantages as few steps, simple operation, cheap and easily available raw materials, mild reaction conditions, and high product yield, and is especially suitable for industrial production of antibiotic linezolid intermediates and antithrombotic drug rivaroxaban intermediates. |
| priorityDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.