| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40627c5bea11948e8a2464065ad7b5fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 |
| filingDate |
2020-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56a28a225c7de40e285179a9c6e2ae0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a328c05681ace3e296bc01c04e936e6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad1fde8a909c331ff39607a8ffaf9ea0 |
| publicationDate |
2022-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3999039-A1 |
| titleOfInvention |
Pretomanid compositions |
| abstract |
Described is an oral pharmaceutical composition including a granulate including a pharmaceutically effective amount of pretomanid or pharmaceutically acceptable solvate thereof. Such granulate may have a bulk density in a range of about 0.3 to 0.8 g/mL and/or a particle size distribution such that no more than about 30 wt.% of the granulate is retained on an ASTM #60 (250µm) sieve. In particular, the composition may provide that at least 40 wt.% of the pretomanid (e.g., at least 60 wt.%) is dissolved within 20 minutes as measured in a USP-II Apparatus at 37± 2° C in 0.5% hexadecyltrimethylammonium bromide (HDTMA) in 0.1N HCl. |
| priorityDate |
2019-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |