| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef8d8a82fd7380682fc0828e58b5f89e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 |
| filingDate |
2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d18d287fe6662d2eacde9f5aa1d76f8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_831f95fda773b06bf58e64a8c9879fd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2c64d9b716fe373551ac4fe970dea79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ae2ed9c84444dfb6e8202bb38f41631
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1dda2722ac67c16cf827c9c349aa213 |
| publicationDate |
2022-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3997094-A1 |
| titleOfInvention |
Camptothecin derivatives with a disulfide moiety and a piperazine moiety |
| abstract |
This invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof (wherein X, Y, Z and n are defined herein). These compounds are useful in the treatment of diseases mediated by topoisomerase I enzyme such as cancers. The present invention also provides processes for the preparation of compounds of Formula I. The compounds of the present invention are more water soluble, stable in buffer solution at various pH, and exhibit better anti-tumor activity and rapid release of SN-38 in tumor microenvironments. |
| priorityDate |
2019-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |