http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3996759-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b1b54f50a3ca3323f279860b5382c2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d81809987f06bdd7af7a94c84b682ecd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-604 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L15-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L15-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L15-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L15-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L15-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L15-22 |
| filingDate | 2020-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fa8b4f89d9db5c269d5268d24257aae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d7bd19016cd16804d9d2c29af205c54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d17680c366d9ec97d9157a846bd9943a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5eac96bbcab7cc7ef63673ce8d5083f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76e48cb2ad1164e7a55268f31c76b9cc |
| publicationDate | 2022-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3996759-A1 |
| titleOfInvention | Biocompatible, flexible, haemostatic sheet |
| abstract | The invention relates to a biocompatible, flexible, haemostatic sheet comprising: • a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; and • distributed within the interstitial space, a plurality of reactive polymer particles comprising (i) a water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups in tissue and blood under the formation of a covalent bond and (ii) a nucleophilic cross-linking agent that contains at least two reactive nucleophilic groups that are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond, said reactive polymer particles having a diameter in the range of 0.5-100 pm and being present in an amount of at least 3% by weight of the fibrous carrier structure. When blood is absorbed by the haemostatic sheet of the present invention, the water-soluble electrophilic polymer in the reactive polymer particles starts dissolving as soon as these particles are 'wetted' by the blood, thereby allowing the electrophilic polymer to react with reactive nucleophilic groups in the blood and tissue, as well as with reactive nucleophilic groups of the nucleophilic cross-linking agent, thereby inducing blood coagulation and tissue sealing, both of which contribute to haemostasis. |
| priorityDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 153.