| abstract |
The present invention provides a novel microsphere capable of drug-loading and a preparation method thereof. The preparation method comprises pre-mixing an aqueous solution of polyvinyl alcohol and hydroxyapatite particles, then adding concentrated hydrochloric acid as a catalyst, and then adding the crosslinking agent glutaraldehyde to obtain the reaction liquid, after 3 seconds-30 seconds of pre-reaction, before the pre-reaction liquid is coagulated, the pre-reaction liquid is added dropwise to the mixture oil phase including liquid paraffin and sorbitan fatty acid ester, and the reaction is continued for at least 3 hours with stirring in an oil bath at 50°C-60°C, and then the reacted mixture is filtered, washed, and dried to obtain microspheres capable of drug-loading. The method of the present invention is conducive to mass production, and the microspheres capable of drug-loading prepared by the method have higher drug loading and encapsulation efficiency, with a good sustained release performance, and the hydroxyapatite particles are embedded in the poly(vinyl alcohol) after the polymerization reaction, makes the microspheres capable of drug-loading have a certain radiopaque function. |