http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3988520-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1074d9060e4dc8cb78490dd30c77f84d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2531-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C13-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C1-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C1-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C13-605 |
| filingDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc9ac1f1e1aadf4a2a2e1e8e59178499 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e7e6e490efcd78546db79ee1946966a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c8261654ee9a9e41b59cc0d3291667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ad88e177245c80aaa508bc57e793dc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33db8592a65c8e3bdaa5e672592feb09 |
| publicationDate | 2022-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3988520-A1 |
| titleOfInvention | Method for continuous synthesis of propellane compounds |
| abstract | Disclosed is a method for continuously synthesizing a propellane compound. The method includes the following steps: using 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane or a derivative thereof as a raw material to form a ring with a lithium metal agent by a continuous reaction, so as to synthesize the propellane compound. A technical scheme of the present disclosure is applied, and a continuous reaction device is used. Continuous feeding, continuous reaction, continuous transfer, and continuous quenching are performed, and the post-treatment may even acquire a separation yield of more than 90%, so the efficient synthesis of the propellane is achieved. In addition, the continuous process is capable of shortening the reaction time, and solving a problem that a product in scale-up production is unstable under an alkaline condition and is deteriorated with the long reaction time; and the use of the continuous process greatly reduces a risk that the lithium reagent is used in the reaction, and it is more beneficial to the scale-up production. |
| priorityDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.