http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3986466-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54e65afc3bec220980be2a4ced7dca4b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-547 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-585 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate | 2020-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef2f0e067f731d674eceee0e0b397839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4170f6d861bd967015e37c0805ece5cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_582cc25334f6f39969ce4ce20eebb965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c22def4ccfa50f1ec43187fe5c19953 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6294ef53e8b1de49b104f1683c5bb989 |
| publicationDate | 2022-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3986466-A1 |
| titleOfInvention | Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as his-tagged proteins via metal complex reagents |
| abstract | The present invention relates to means and methods for conjugating/ attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) nitrate as a metal cation ligand and (ii) a metal cation chelating domain comprising a chelating ligand and a label and/or carrier. This complex can be used for attaching a label and/or a carrier to a target molecule, preferably a protein. The attachment of the label or carrier via the complex of the invention involves the replacement of the metal cation ligand with a coordinating group of the target molecule so that a product complex with the target molecule as primary ligand in the coordination sphere of the metal cation is formed. Accordingly, the present invention also provides for uses and methods involving the attachment of a label and/or carrier to a target molecule. Also provided are the products obtained by the labeling and or carrier-attaching methods of the invention and uses thereof. The invention further relates to methods for producing the complex of the invention and kits comprising the components for producing the complex of the invention. |
| priorityDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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