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publicationDate 2022-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3983523-A1
titleOfInvention Improvements in and relating to the monitoring of cell expansion
abstract Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.
priorityDate 2019-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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