| abstract |
The present invention pertains to a novel sealant, glue or filler for biological tissues based on a biodegradable, cross-linkable fusion protein having the formula (I) ULD-(L)<sub>n</sub>-ULD, wherein ULD is an ubiquitin-like-domain, forming tetrameric protein structures, and (L) is a linker sequence, preferably a peptide or protein sequence having 5-2500 aa. The particular advantage of the current system lies in its great variability and low toxicity towards the recipient biological tissue, preferably a mammalian, e.g. a human, or any animal species. Moreover, the novel tissue sealant allows providing sealants, glues or fillers with high elasticity, adhesiveness and high resistance, which can be applied to a (wet) biological tissue within minutes. The present invention also pertains to medical uses of the novel biological tissue sealant, glue or filler and to methods of treatment using the same. |