| abstract |
The present invention relates to compounds of the general formula I:wherein:Q is a lipophilic, zinc chelating moiety which is selective for Zn<sup>2+</sup> ions and which comprises at least one, preferably two or more (e.g 2, 3 or 4), optionally substituted, unsaturated heterocyclic rings, e.g. 5 or 6-membered heterocyclic rings (such rings preferably include at least one heteroatom selected from N, S and O, preferably N); wherein any optional substituents may be selected from C<sub>1-6</sub> alkyl, C<sub>1-6</sub> alkoxy, halogen, nitro, cyano, amine, and substituted amine;each L, which may be the same or different, is a covalent bond or a linker;each W, which may be the same or different, is a non-peptidic hydrophilic group which comprises a boronic acid; andx is an integer from 1 to 3)or a stereoisomer or pharmaceutically acceptable salt thereof,and their use in a method of treating and/or preventing a bacterial infection in a human or nonhuman mammal. |