http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3969049-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3307f8a72c8c008ae0b440110327163 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_058a6aadbbc510b897bccd20af10541a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6909 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6901 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0028 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e430c64c82313ea9fb3a59270bd6c9af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93ddf12c79cc0109b7f5cc19f0037d62 |
| publicationDate | 2022-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3969049-A1 |
| titleOfInvention | A light-triggerable nanoparticle library of formulations for the controlled release of rnas |
| abstract | The present application relates to a triggerable polymeric nanoparticle (NP) library composed by several formulations, presenting physico-chemical diversity and differential responsiveness to light. In certain applications, six formulations were more efficient (up to 500%) than commercial Lipofectamine in gene knockdown activity. These formulations had differential internalization by skin cells and the endosomal escape was rapid (minutes range) as shown by the recruitment of galectin 8. The NPs described were effective in the release of siRNA and miRNA but can also be extended to the release of mRNA and other types of RNA. Acute skin wounds treated with the top hit NP complexed with miRNA-150-5p healed faster than wounds treated with scramble miRNA. Thus, light-triggerable NPs offer a new strategy to deliver topically non-coding and coding RNAs. |
| priorityDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 361.