| abstract |
The present disclosure relates to a modified mesenchymal stem cell culture medium, a bone marrow mesenchymal stem cell and a culture method and use thereof, the modified mesenchymal stem cell culture medium comprising a basal culture medium, a first component, and melatonin, wherein the first component is at least one selected from the group consisting of coenzyme Q10 and mitoquinone mesylate, and has a working concentration in a range from 1 µM to 20 µM, the melatonin has a working concentration in a range from 1 µM to 20 µM, and the first component and the melatonin are in a molar ratio ranging from 1:0.2 to 1:10. The modified mesenchymal stem cell culture medium can increase the mitochondrial activity and the number of mitochondria in mesenchymal stem cells. |