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filingDate 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3737923d13335c9742cd56dbe225cdce
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publicationDate 2022-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3946633-A1
titleOfInvention Engineering of an antibody for tumor-selective binding of cd47
abstract Antibodies are provided which comprise at least one Fab portion that binds CD47 and at least one Fab portion that binds the tumor associated antigen (TAA) CD20; wherein the Fab portion that binds CD47 exhibits low affinity for CD47; and, wherein the Fab portion that binds CD20 exhibits high affinity for CD20; and, wherein the antibody selectively binds CD47 and blocks CD47 interaction with SIRPĪ± in tumor cells while exhibiting no substantial binding to CD47 in normal cells.
priorityDate 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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