| abstract |
The invention relates to: An injectable aqueous implant formulation for use in oral tissue regeneration which has been sterilized by gamma-ray or X-ray- irradiation and can be extruded through a tapering system and an 18 gauge (0.838 mm inner diameter) 25.4 mm long cannula with a force not exceeding 60 N, which comprises 25-45 w/w % of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 pm as determined by sieving and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of nanocrystalline hydroxyapatite to collagen is from 1.8 to 4.5, which contains at least 0.05 % (w/w) ascorbic acid, and a process for preparing the above injectable aqueous implant formulation |