http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3936503-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd033194bff33dd6f2ca05bffaff2262 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-225 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421b1088a50836f19e99f8df2567bdb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03b79bf597542ad6a073943d5e5615d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e9b61230f7f12e121b03014f0c44b5c |
| publicationDate | 2022-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3936503-A1 |
| titleOfInvention | Process and intermediates for the preparation of pyroxasulfone, fenoxasulfone and various sulfone analogs of 5,5-dimethyl-4h-1,2-oxazole |
| abstract | The invention relates to a process for preparing immediate precursors for pyroxasulfone and fenoxasulfone preparation of the formula (I). The process comprises a bromination reaction of a benzylic position without light irradiation (step a ), followed by thoination reaction, which substitutes the bromine atom (step b ) and after the protecting group is removed, and the revealed thiol or thiolate reacts with a substituted isoxazoline bearing a leaving group at the 3-position (step c ).n nwherein nY = protecting group n In another variant of the invention the pyroxasulfone or fenoxasulfone immediate precursor is synthesized from the arylmethyl bromide by first forming a carbon-sulfur bond at the 3-position of a 2-isoxazoline through displacement of a leaving group at the 3-position (particularly acid derived residues such as phosphoryl, sulfanyl, halo, cyano or carboxyl groups) by an appropriate thionating reagent. The resulting adducts, which is a S-protected 3-thio-2-isoxazoline, may be treated with base to remove the protecting group, to reveal a thiol or thiolate which may subsequently react with the arylmethyl bromide to form the Pyroxasulfone or Fenoxasulfone immediate precursor.n nAr = aryl, Y = protecting group and X = leaving group |
| priorityDate | 2020-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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