http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3932940-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d0e1705700a059b200c774b76ce1234 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43545 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766837518238f987c8d20942760dcc32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd08535d7ae632be37d2c62d5ae676b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_215c24ed8397e618ff61342bb744409c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_877b2319194831718d5060fc97535093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_feb5ef5536235b436e6e8d72f9064677 |
| publicationDate | 2022-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3932940-A1 |
| titleOfInvention | Polypeptides for light induced ca2 release and constructs containing the same |
| abstract | The present invention relates in a first aspect to a polypeptide comprising a channelrhodopsin moiety, a linker moiety and a moiety of a Ca 2+ sensitive protein. In particular, the polypeptide is a polypeptide composed of the channelrhodopsin-2 of Chlamydomonas reinhardtii , a linker and RyR2 whereby the linker is designed to establish a distance of from 100 to 200 Angstrom between the channelrhodopsin moiety and the RyR2 moiety when present in a cellular membrane of eukaryotes. In addition, nucleic acid molecules encoding the polypeptide according to the present invention as well as vector or vector systems containing said nucleic acid molecule. Further, nucleic acid constructs comprising the nucleic acid encoding the polypeptide of the channelrhodopsin as well as the linker is provided. In addition, isolated cells, cell lines or host cells containing the vector or vector system according to the present invention or expressing the polypeptide according to the present invention are provided. Further, the C. elegans strains containing the vector according to the present invention or expressing the polypeptide according to the present invention are provided. Method for determining the activity of potential principal actives on Ca 2+ sensitive proteins are provided based on determining the activity of these molecules on said Ca 2+ sensitive protein. |
| priorityDate | 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.