| abstract |
The present disclosure provides compositions and methods for treating an autoimmune disorder or cancer in a subject. In some embodiments, the methods include the use of modified T cells (e.g., CD8+ T cells) that have high layilin expression. In other embodiments, the methods include the use of layilin-binding proteins. Also provided herein are methods and compositions for identifying modulators of layilin or beta-integrin complex interaction. |