http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3919487-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6c3687760b3eef5299c1dba1fb0e275 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 |
| filingDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f4b84a02a3e845507767e44d9dd4500 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab610e2f3d7dd7966c3f4beb9d11308e |
| publicationDate | 2021-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3919487-A1 |
| titleOfInvention | Preparation method and application of gadolinium ionic contrast agent intermediate |
| abstract | The present invention provides a preparation method and application of an intermediate of gadolinium-based ionic contrast agent. The preparation method comprises the following step: allowing a substance represented by the general formula (II) to react a substance represented by the general formula (III) or a substance represented by the general formula (IV) in the presence of a basic catalyst to generate an intermediate of gadolinium-based ionic contrast agent containing the structure represented by the general formula (I) or the general formula (V), wherein R represents C<sub>1</sub>-C<sub>5</sub> alkyl, benzyl or benzyl derivative, R<sub>1</sub> represents -H or -CH<sub>2</sub>OH, and R<sub>2</sub> represents -CH<sub>3</sub> or -OH. When preparing an intermediate of gadolinium-based ionic contrast agent having the structure represented by the general formula (I) using the above-mentioned preparation method, it can provide the advantages of simple reaction, fewer steps, controllable reaction, a yield up to 99% or more, and a purity greater than 99.5% for the obtained product. |
| priorityDate | 2019-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.