| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_661b3ea63e73acc96731eb73625b1bc2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3521
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2012-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7af5f88ddff5142136c0665ba24b2b2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ff38eee88fd976ad2387245e5ca7881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9911f49395597ec7d02fc721b8a4d28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_428b4d3864806d779b7ee8d495fd59c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e130862eb1a8e830841064c29482037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1968c08a2322df01797b879e1962d8b8 |
| publicationDate |
2021-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3913056-A1 |
| titleOfInvention |
Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| abstract |
The present invention relates to a double stranded RNAi agent comprising a sense strand complementary to an antisense strand, wherein said antisense strand comprises a region substantially complementary to nucleotides 504 to 526 of the transthyretin (TTR) gene of SEQ ID NO: 1, wherein the sense strand is 21 nucleotides in length and the antisense strand is 23 nucleotides in length, wherein said double stranded RNAi agent comprises the sense strand represented by the following formula (I): 5' n<sub>p</sub> -N<sub>a</sub> -(X X X)<sub>i</sub>-N<sub>b</sub> -Y Y Y -N<sub>b</sub> -(Z Z Z)<sub>j</sub> -N<sub>a</sub> - n<sub>q</sub> 3' (I) wherein: i is 1 and j is 0; or i is 0 and j is 1; or both i and j are each independently 0 or 1; p and q are each independently 0-6; each N<sub>a</sub> independently represents an oligonucleotide sequence comprising 0-25 modified nucleotides, each sequence comprising at least two differently modified nucleotides; each N<sub>b</sub> independently represents an oligonucleotide sequence comprising 0-10 modified nucleotides; each n<sub>p</sub> and n<sub>q</sub> independently represents an overhang nucleotide; XXX, YYY and ZZZ each independently represent one motif of three identical modifications on three consecutive nucleotides; modifications on N<sub>b</sub> differ from the modification on Y; wherein YYY is all 2'-F modified nucleotides; and wherein the sense strand is conjugated to at least one ligand, wherein the ligand is a Ga1NAc ligand at 3' end. |
| priorityDate |
2011-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |