| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd15fea28fa5c3272dd3e41dcf3b0dd3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-413
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-0241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2020-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_916c644faddf1bb8956fb22dd0af4ad4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6725b631ca3ec379d8daf732e544201
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_682012cc2f92f8711bda4921dd31c9d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd5790120ccada445964a00bc304996
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_962cd06da34a40550ba45edf573cff22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab99e4569a6564290fbdd34d96146269
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31cbdb371064da4414b601c5bc942e97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22c90209c971a62f841f7b38a6d97949
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c430dd596b58e13205de17b57d37a57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdd74e128d2ff07ef8ee68aee397561c |
| publicationDate |
2021-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3913055-A1 |
| titleOfInvention |
Double-stranded oligonucleotide targeting dkk1 gene, construct including same, and hair loss prevention or hair growth composition containing same |
| abstract |
The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth. |
| priorityDate |
2019-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |