| abstract |
The present disclosure relates to devices and systems for targeted and controlled delivery of a therapeutic agent to a treatment site of an eye. Particularly, aspects are directed to a therapeutic agent delivery device (200) that includes a polymeric substrate (205) having a release region (210), a delivery region, and a receiving region; one or more reservoirs (215) formed within the release region (210); a therapeutic agent disposed within the one or more reservoirs (215); an active, passive, or combination thereof controlled release mechanism for release of the therapeutic agent from the one or more reservoirs (215) into the delivery region; and a circuit (275) formed on the polymeric substrate (205), the circuit (275) having a current source, a first iontophoresis electrode located within the delivery region for transport of the therapeutic agent from the delivery region into a target tissue via electromigration, and a second iontophoresis electrode located within the receiving region for maintaining electroneutrality within the tissue. |