http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3907215-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba691e6c807a1a62a286bfc83e5b4ba9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0239 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0271 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76 |
| filingDate | 2019-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c51f273bcfb0cc85367724140fb78f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ddace54c3e57e2aee8a6e2beb8e297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a1e61318b43798739c52888d89741d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1aa282d5db8ce28b9b7bc085cf4d85f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b1a94a5375cc9b8abf68595f0591fc7 |
| publicationDate | 2021-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3907215-A1 |
| titleOfInvention | Synthesis method for candesartan cilexetil intermediate |
| abstract | A synthesis method for a candesartan cilexetil intermediate represented by formula (II). The method comprises: (1) dissolving a compound represented by formula (IV) to an aprotic solvent to obtain a first mixed solution, and dissolving a phase transfer catalyst and an azidation reagent to water to obtain a second mixed solution; (2) dropping the first mixed solution to the second mixed solution for azidation reaction, and after the reaction is ended, standing and layering same to obtain an organic phase containing a compound represented by formula (V); (3) dropping the obtained organic phase containing the compound represented by formula (V) to tertiary butyl alcohol for rearrangement reaction, and after the reaction is ended, concentrating same to obtain a solid or oily material, then adding a crystallizing solvent to the obtained solid or oily material for recrystallization, and separating same to obtain a crystal, i.e., the candesartan cilexetil intermediate represented by formula (II). The synthesis method of the present application does not require the use of a DMF solvent, is safe and environmentally friendly, and reduces generation of ammonia nitrogen wastewater. |
| priorityDate | 2019-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.