| abstract |
The present invention provides a bio-ink composition comprising a plurality of bio-blocks, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. Also provided are methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs (such as composite constructs). Further provided are bio-blocks, pharmaceutical compositions comprising the bio-blocks, and methods of preparing the bio-blocks. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine. |