http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3903787-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc9c64c689609c65e86ff60925f6aa05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75752c61f4a6e3bef7d6532e2f491c55 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a9251a1481f04057ac752b61b1d44de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d84e511819f9fe9a51b2ff03b0e0ee5 |
| publicationDate | 2021-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3903787-A1 |
| titleOfInvention | Nanoparticle-based vaccine targeting cancer/testis antigens (cta) and its use in solid and hematological malignancies |
| abstract | The present disclosure relates to antitumor vaccine compositions for oral administration. Disclosed herein are vaccine compositions comprising microparticles, wherein the particles comprise a gastric acid resistant, enteric erodable matrix comprising beta cyclodextrin and hydroxypropylmethyl cellulose acetate succinate (HPMCAS). The vaccine particles described herein encapsulate one or more cancer testis antigens (CTA), and an M-cell targeting lectin such as aleuria aurantia lectin (AAL), the lectin being present in a microfold cell (M-cell) targeting effective amount; and an aqueous vehicle in which said nanoparticles are suspended. In another aspect the present disclosure relates to assemblies of the microparticles themselves. Lastly, disclosed are methods of treating cancer by immunizing subjects in need of treatment with the foregoing vaccine compositions. |
| priorityDate | 2014-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.