| abstract |
Provided herein are cell lines ( e.g. , HEK293 cell lines) that comprise a loss-of-function mutation in each of the human Bax and Bak genes, as well as cell cultures comprising the cell lines. The cell lines and/or cell cultures may find use, e.g. , in methods for producing a recombinant polypeptide (such as an antibody or antigen-binding fragment thereof) or a viral vector. |