Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1afbda65696a2d50a088a3588bf0caa3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5406 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 |
filingDate |
2019-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea41070d0fdc3b84f8c0f65cdf2f7a98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42da715badb6fc88bcd331071c5638d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d9a66eec203f62899f8f78d0de9bc3b |
publicationDate |
2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-3885357-A1 |
titleOfInvention |
Interleukin 21 protein (il21) mutant and use thereof |
abstract |
The invention relates to an interleukin-21 protein (IL21) mutant and application thereof. The mutant is with ILE at position 16 and SER at position 70 of the amino acid sequence of the wild-type IL21 both mutating into CYS, and a disulfide bond forming between the two mutated CYSs. The amino acid sequence of the wild-type IL21 is shown in SEQ ID NO.1.The invention also relates to a fusion protein containing the IL21 mutant protein and a use of the IL21 mutant protein or the fusion protein in the preparation of a medicine and, preferably, the medicine regulates or activates immunity or are an anti-tumor medicine. The invention also relates to the use of the IL21 mutant, the IL21/4 mutant or the fusion protein in the preparation of a formulation for promoting the differentiation and proliferation of B cell, the differentiation and proliferation of T cell, the differentiation and proliferation of NK cell. |
priorityDate |
2018-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |