| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-805
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1211
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-22062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate |
2019-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c3ffbbf948cee1a860c5b4f593c504
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33743f9c5b9311d619e13d49d161081c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b18bd9a962979374419b775f22d0ccce |
| publicationDate |
2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3884055-A1 |
| titleOfInvention |
Double and inducible suicide gene construct and its use in gene therapy |
| abstract |
The present invention provides a double and inducible suicide gene construct that combines the cell death-inducing capacity of the two suicide systems HSV-TK/GCV and iCaspase9/AP20187 in a single polycistronic cassette. The invention also relates to an expression vector comprising said construct, a cell comprising said construct or said vector, pharmaceutical compositions comprising these products and their applications as a medicament for the genetic safety for inducing the specific and directed cell death of specific cell populations that are causing adverse effects in the interior of an organism. The present invention is applicable, for example, in cancer treatments or in transplant situations where the transplanted cells are giving rise to immune rejection or to the formation of tumors. |
| priorityDate |
2018-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |