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filingDate 2019-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3880637-A1
titleOfInvention Continuos flow synthesis of cannabidiol
abstract A process for the synthesis of Cannabidiol of formula (1): (1) is herein disclosed. The process comprises contacting a solution [solution (S1)] of (+)-p-mentha-diene-3-ol of formula (4) (4) or an ester thereof and olivetol of formula (3): (3) with a solution [solution (S2)] of a non-supported Lewis acid in a continuous flow reactor and treatment of the resulting mixture with a basic solution. The process offers the advantage that it can be conveniently carried out on an industrialscale while avoiding the formation of abnormal CBD and THC (Δ9-tetrahydrocannabinol).
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